2. Academic Validation
  3. Dual-modified liposome codelivery of doxorubicin and vincristine improve targeting and therapeutic efficacy of glioma

Dual-modified liposome codelivery of doxorubicin and vincristine improve targeting and therapeutic efficacy of glioma

  • Drug Deliv. 2017 Nov;24(1):1045-1055. doi: 10.1080/10717544.2017.1344334.
Yue Zhang 1 2,  Meifang Zhai 1 3,  Zhijiang Chen 1 2,  Xiaoyang Han 4,  Fanglin Yu 1,  Zhiping Li 1,  Xiangyang Xie 5,  Cuiyan Han 6,  Lian Yu 3,  Yang Yang 1,  Xingguo Mei 1
Affiliations

Affiliations

  • 1 a State key Laboratory of Toxicology and Medical Countermeasure, Department of Pharmaceutics , Beijing Institute of Pharmacology and Toxicology , Beijing , PR China.
  • 2 b Hubei University of Science and Technology , Xianning , PR China.
  • 3 c Jiamusi University , Jiamusi , PR China.
  • 4 d Outpatient Department of Beijing Space City , Aerospace Systems Divison, PLA Strategic Support Force , Beijing , PR China.
  • 5 e Department of Pharmacy , Wuhan General Hospital of the Chinese People's Liberation Army , Wuhan , PR China.
  • 6 f School of Pharmacy , Qiqihar Medical University , Qiqihar , PR China.
PMID: 28687044 DOI: 10.1080/10717544.2017.1344334
Abstract

Therapeutic outcome for the treatment of glioma was often limited due to drug resistance and low permeability of drug across the multiple physiological barriers, including the blood-brain barrier (BBB), and the blood-tumor barrier (BTB). In order to overcome these hurdles, we designed T7 and DA7R dual peptides-modified liposomes (abbreviated as T7/DA7R-LS) to efficiently co-delivery doxorubicin (DOX) and vincristine (VCR) to glioma in this study. T7 is a seven-peptide ligand of transferrin receptors (TfR) capable of circumventing the BBB and then targeting glioma. DA7R is a d-peptide ligand of vascular endothelial growth factor receptor 2 (VEGFR 2) overexpressed on angiogenesis, presenting excellent glioma-homing property. By combining the dual-targeting delivery effect, the dual-modified liposomes displayed higher glioma localization than that of single ligand-modified liposomes or free drug. After loading with DOX and VCR, T7/DA7R-LS showed the most favorable antiglioma effect in vivo. In conclusion, this dual-targeting, co-delivery strategy provides a potential method for improving brain drug delivery and antiglioma treatment efficacy.

Keywords

DA7R peptide; T7 peptide; brain targeted drug delivery; doxorubicin; glioma; vincristine.

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