2. Academic Validation
  3. Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus

Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus

  • Phytochemistry. 2017 Nov;143:98-103. doi: 10.1016/j.phytochem.2017.07.013.
Zeynep Tohtahon 1,  Jingjing Xue 2,  Jianxin Han 1,  Yushuang Liu 1,  Huiming Hua 2,  Tao Yuan 3
Affiliations

Affiliations

  • 1 The Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • 2 Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • 3 The Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China. Electronic address: [email protected].
PMID: 28800422 DOI: 10.1016/j.phytochem.2017.07.013
Abstract

Chemical investigation of a bioactive methanolic extract of the fruiting bodies of Piptoporus betulinus led to the isolation of five previously undescribed lanostane triterpenoids named piptolinic acids A-E, as well as five known lanostane triterpenoids. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic and HRESIMS analysis. Piptolinic acid A with an unusual moiety (3-hydroxy-4-methoxycarbonyl-3-methylbutyryloxy) at C-3 exhibited comparable cytotoxic activity against human promyelocytic leukemia cell line HL-60 (IC50 = 1.77 μM) and human acute monocytic leukemia cell line THP-1 (IC50 = 8.21 μM) to those of positive control, fluorouracil (IC50 = 6.38 and 4.41 μM, respectively).

Keywords

Cytotoxicity; HL-60; Lanostane triterpenoid; Piptoporus betulinus; Polyporaceae.

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