2. Academic Validation
  3. Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

  • J Cancer. 2017 Jul 3;8(10):1900-1907. doi: 10.7150/jca.17689.
Pramod Kumar Maurya 1,  Alok Mishra 1,  Birendra Singh Yadav 1,  Swati Singh 2,  Prashant Kumar 1,  Amit Chaudhary 1,  Shweta Srivastava 1,  Suriya Narayan Murugesan 1,  Ashutosh Mani 1
Affiliations

Affiliations

  • 1 Department of Biotechnology, MNNIT Allahabad-211004.
  • 2 Center of Bioinformatics, University of Allahabad, Allahabad-211002.
PMID: 28819388 DOI: 10.7150/jca.17689
Abstract

The Y-box binding protein (YB-1) is known to be a multifunctional transcription and translation factor during expression of several proteins. It is a vital oncoprotein that regulates Cancer cell progression and proliferation. YB-1 is over-expressed in various human cancers such as breast Cancer, colon Cancer, lung Cancer, gastric Cancer, oesophageal Cancer and glioblastoma. Nuclear expression of YB-1 is found to be associated with multidrug resistance and Cancer cell progression. YB-1 is reported to regulate many cellular signalling pathways in different types of Cancer proliferation. Knowledge about nuclear localization and nuclear level expression of YB-1 in different cancers has been correlated with prospective prognosis of Cancer. This review discusses the prospects of YB-1 as a potential biomarker as well as therapeutic target in lieu of their role during Cancer progression and multidrug resistance.

Keywords

Y Box Protein-1; biomarker; cancer.

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