2. Academic Validation
  3. Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica

Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica

  • Nat Prod Res. 2018 Sep;32(18):2127-2132. doi: 10.1080/14786419.2017.1366476.
Chihiro Ito 1,  Takuya Matsui 1 2,  Makiko Takano 1,  Tian-Shung Wu 3,  Masataka Itoigawa 4
Affiliations

Affiliations

  • 1 a Faculty of Pharmacy , Meijo University , Tempaku , Japan.
  • 2 b Department of Physiology , Aichi Medical University , Nagakute , Japan.
  • 3 c Department of Chemistry , National Cheng Kung University , Tainan , Taiwan.
  • 4 d School of Sport and Health Science , Tokai Gakuen University , Miyoshi , Japan.
PMID: 28823173 DOI: 10.1080/14786419.2017.1366476
Abstract

Study of the chemical constituents of the roots of Plumbago zeylanica L. collected in Taiwan led to the isolation and identification of a new naphthoquinone dimer, plumzeylanone (1), along with eight known compounds (2-9). Nine naphthoquinones isolated from this plant were assayed for cell growth inhibition activity using NALM-6 (human B cell precursor leukaemia), A549 (human lung adenocarcinoma), Colo205 (human colorectal adenocarcinoma) and KB (human epidermoid carcinoma). Plumzeylanone (1), a novel plumbagin dimer, suppressed cell proliferation in only NALM-6 cells (IC50 3.98 μM). However, maritinone (9) showed strong inhibition of cell growth in all cell lines tested (0.12 < IC50 < 9.06 μM). This compound appeared to affect the cell cycle.

Keywords

Plumbaginaceae; Plumbago zeylanica; cell cycle; cell proliferation; naphthoquinones.

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