2. Academic Validation
  3. Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

  • Oncotarget. 2017 Sep 4;8(43):75467-75477. doi: 10.18632/oncotarget.20636.
Yuanyuan Zou 1,  Xi Zhang 1,  Jingyi Zhang 1,  Xiangning Ji 1,  Yuqing Liu 1
Affiliations

Affiliation

  • 1 The Second Department of Ophthalmology, Cangzhou Central Hospital, 061001, Cangzhou, PR China.
PMID: 29088882 DOI: 10.18632/oncotarget.20636
Abstract

We performed a meta-analysis to investigate the association between the Factor V G1691A polymorphism and the risk of retinal vein occlusion (RVO). This analysis included 37 studies involving 2,510 cases and 3,466 controls. Factor V G1691A was associated with an increased risk of RVO in the allele, heterozygote, dominant, and carrier models (PA < 0.001, odds ratios >1), but not the homozygote or recessive models (PA > 0.05). Similar results were observed in a meta-analysis of central retinal vein occlusion (CRVO) and when comparing Caucasian subgroups to population-based controls. These data demonstrate that the G/A genotype of Factor V G1691A is associated with an increased risk of RVO/CRVO in a Caucasian population.

Keywords

factor V; meta-analysis; polymorphism; retinal vein occlusion.

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