2. Academic Validation
  3. The 2-desamino and 2-desamino-2-methyl analogues of aminopterin do not inhibit dihydrofolate reductase but are potently toxic to tumor cells in culture

The 2-desamino and 2-desamino-2-methyl analogues of aminopterin do not inhibit dihydrofolate reductase but are potently toxic to tumor cells in culture

  • J Med Chem. 1989 Mar;32(3):517-20. doi: 10.1021/jm00123a001.
A Rosowsky 1,  R A Forsch,  J H Freisheim,  R G Moran
Affiliations

Affiliation

  • 1 Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
PMID: 2918496 DOI: 10.1021/jm00123a001
Figures