2. Academic Validation
  3. Oxazole-Containing Diterpenoids from Cell Cultures of Salvia miltiorrhiza and Their Anti-HIV-1 Activities

Oxazole-Containing Diterpenoids from Cell Cultures of Salvia miltiorrhiza and Their Anti-HIV-1 Activities

  • J Nat Prod. 2017 Dec 22;80(12):3241-3246. doi: 10.1021/acs.jnatprod.7b00659.
Dewu Zhang 1,  Jiamei Guo 1,  Min Zhang 1,  Xiao Liu 1,  Mingyu Ba 1,  Xiaoyu Tao 1,  Liyan Yu 1,  Ying Guo 1,  Jungui Dai 1
Affiliations

Affiliation

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, and ‡Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
PMID: 29185738 DOI: 10.1021/acs.jnatprod.7b00659
Abstract

Four new oxazole-containing Diterpenoids, salvianans A-D (1-4), along with three known Diterpenoids (5-7), were isolated from Salvia miltiorrhiza cell cultures. The structures of the new compounds were elucidated using spectroscopic methods and single-crystal X-ray diffraction. The evaluation for their anti-HIV-1 activities revealed that 2 and 3 displayed inhibitory activities with IC50 values of 0.03 and 1.2 μM, respectively. The time of addition (TOA) assay and long terminal repeat (LTR) luciferase reporter assay results indicated that compound 2 was an HIV-1 transcription inhibitor and might be a lead compound of Antiviral agents acting on HIV-1 transcription.

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