2. Academic Validation
  3. Cytotoxic oligophenols from the rhizome of Wikstroemia indica

Cytotoxic oligophenols from the rhizome of Wikstroemia indica

  • Bioorg Med Chem Lett. 2018 Feb 15;28(4):626-629. doi: 10.1016/j.bmcl.2018.01.036.
Qirui Wang 1,  Yiping Jiang 2,  Chaohua Luo 1,  Ruichen Wang 1,  Sui Liu 1,  Xiaojun Huang 3,  Meng Shao 4
Affiliations

Affiliations

  • 1 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
  • 2 Department of Pharmacy, Zhuhai People's Hospital, Zhuhai 519000, China.
  • 3 Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: [email protected].
  • 4 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. Electronic address: [email protected].
PMID: 29395979 DOI: 10.1016/j.bmcl.2018.01.036
Abstract

A new tricoumarin glycoside, triumbelletin-7-O-β-d-glucoside (1) and a new biflavonoid, wikstroflavone A (2), together with two known compounds, wikstaiwanone A (3) and wikstaiwanone B (4), were isolated from the rhizome of Wikstroemia indica. The structures of new compounds were elucidated by extensive spectroscopic techniques (UV, IR, HRESIMS, 1D, 2D NMR and CD), in combination with quantum chemical calculations of 13C NMR and ECD spectra. All isolates were tested for their antineoplastic activities against cancer-derived cell lines HCT116, SW480, U87 and T98G. Compounds 2-4 exhibited moderate cytotoxic activities to the four cell lines. The flow cytometry assay and western blot analysis revealed that the cytotoxic effects were possibly attributed to the induced apoptotic cell death.

Keywords

Biflavonoid; Cytotoxicity; Oligophenol; Tricoumarin glycoside; Wikstroemia indica.

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