Functions of PDE3 Isoforms in Cardiac Muscle

J Cardiovasc Dev Dis. 2018 Feb 6;5(1):10. doi: 10.3390/jcdd5010010.

Matthew Movsesian ¹, Faiyaz Ahmad ², Emilio Hirsch ³

Affiliations

1 Department of Internal Medicine/Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT 841132, USA. [email protected].
2 Vascular Biology and Hypertension Branch, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. [email protected].
3 Department of Molecular Biotechnology and Health Sciences, Center for Molecular Biotechnology, University of Turin, 10126 Turin, Italy. [email protected].

PMID: 29415428 DOI: 10.3390/jcdd5010010

Abstract

Isoforms in the PDE3 family of cyclic nucleotide phosphodiesterases have important roles in cyclic nucleotide-mediated signalling in cardiac myocytes. These Enzymes are targeted by inhibitors used to increase contractility in patients with heart failure, with a combination of beneficial and adverse effects on clinical outcomes. This review covers relevant aspects of the Molecular Biology of the isoforms that have been identified in cardiac myocytes; the roles of these Enzymes in modulating cAMP-mediated signalling and the processes mediated thereby; and the potential for targeting these Enzymes to improve the profile of clinical responses.

Keywords

PDE3; cAMP; cGMP; cyclic nucleotides; heart; intracellular signalling; phosphodiesterase.

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