2. Academic Validation
  3. Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy

Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy

  • Clin Transl Sci. 2018 Jul;11(4):352-364. doi: 10.1111/cts.12551.
Pascale Fisel 1 2,  Elke Schaeffeler 1 2,  Matthias Schwab 1 2 3 4 5
Affiliations

Affiliations

  • 1 Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
  • 2 University of Tübingen, Tübingen, Germany.
  • 3 Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen, Germany.
  • 4 Department of Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany.
  • 5 German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
PMID: 29660777 DOI: 10.1111/cts.12551
Abstract

The solute carrier (SLC) SLC16 gene family comprises 14 members and encodes for monocarboxylate transporters (MCTs), which mediate the absorption and distribution of monocarboxylic compounds across plasma membranes. As the knowledge about their physiological function, activity, and regulation increases, their involvement and contribution to Cancer and Other Diseases become increasingly evident. Moreover, promising opportunities for therapeutic interventions by directly targeting their endogenous functions or by exploiting their ability to deliver drugs to specific organ sites emerge.

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