2. Academic Validation
  3. Seven new anthranilamide derivatives from Aconitum apetalum

Seven new anthranilamide derivatives from Aconitum apetalum

  • Fitoterapia. 2018 Jul:128:73-78. doi: 10.1016/j.fitote.2018.05.008.
Zhan-Xing Hu 1,  Li-Hua Zhao 2,  Hong-Yu Tang 3,  Haji Aker Aisa 4,  Yu Zhang 5,  Xiao-Jiang Hao 6
Affiliations

Affiliations

  • 1 The Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Yuquan Road 19, Beijing 100049, PR China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
  • 2 The Institute of Biotechnology and Germplasm Resources, Yunnan Academy of Agricultural Sciences, Kunming 650204, PR China.
  • 3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
  • 4 The Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China.
  • 5 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: [email protected].
  • 6 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China. Electronic address: [email protected].
PMID: 29772296 DOI: 10.1016/j.fitote.2018.05.008
Abstract

Seven new anthranilamide derivatives, acoapetalines A-G (1-7), including one new naturally occurring compound (7), together with six known ones (8-13) were isolated from the whole Plants of Aconitum apetalum. Their structures were established on the basis of extensive spectroscopic analyses (IR, UV, HRESIMS, 1D and 2D NMR). All compounds were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 10 exhibited significant anti-TMV activity with an inhibition rate of 67.57% (100 μg/mL), which was higher than that of ningnamycin (52.89%).

Keywords

Aconitum apetalum; Anthranilamide derivatives; Anti-TMV.

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