2. Academic Validation
  3. Easy-to-Use Colorimetric Cyanine Probe for the Detection of Cu2+ in Wilson's Disease

Easy-to-Use Colorimetric Cyanine Probe for the Detection of Cu2+ in Wilson's Disease

  • ACS Appl Mater Interfaces. 2018 Jun 20;10(24):20377-20386. doi: 10.1021/acsami.8b07081.
Yibing Shi 1,  Roumin Wang 2,  Wei Yuan 1,  Qingyun Liu 1,  Mei Shi 1,  Wei Feng 1,  Zhiying Wu 2,  Ke Hu 1,  Fuyou Li 1
Affiliations

Affiliations

  • 1 Department of Chemistry & State Key Laboratory of Molecular Engineering of Polymers & Institute of Biomedicine Sciences & Collaborative Innovation Center of Chemistry for Energy Materials , Fudan University , 220 Handan Road , Shanghai 200433 , P. R. China.
  • 2 Department of Neurology and Research Center of Neurology, Second Affiliated Hospital , Zhejiang University School of Medicine , 88 Jiefang Road , Hangzhou , Zhejiang 310009 , P. R. China.
PMID: 29851344 DOI: 10.1021/acsami.8b07081
Abstract

Copper(II) is one of the essential metal elements in human body, which can accumulate in many organs and finally excrete in urine. Excessive load of Cu2+ can cause liver cirrhosis, kidney dysfunction, and many neurological symptoms in the case of Wilson's disease (WD). Therefore, the selective and efficient detection of Cu2+ is of great importance. Although various fluorescent probes have been reported for the detection of Cu2+, an efficient and capable probe is still rare for patients' self-use on a routine basis. In this study, we developed an easy-to-use probe CY1 based on UV-vis-near-infrared absorption changes with excellent sensitivity and selectivity for Cu2+. The mechanism of oxidation of CY1 by Cu2+ was first explored. We demonstrated the role of the probe in the quantitative detection of Cu2+ in urine from WD patients and showed that it has great potential for clinical applications.

Keywords

Wilson’s disease; colorimetric probe; cyanine dye; dopamine; urinary copper detection.

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