2. Academic Validation
  3. Scabiosa stellata L. Phenolic Content Clarifies Its Antioxidant Activity

Scabiosa stellata L. Phenolic Content Clarifies Its Antioxidant Activity

  • Molecules. 2018 May 27;23(6):1285. doi: 10.3390/molecules23061285.
Naima Rahmouni 1 2,  Diana C G A Pinto 3,  Noureddine Beghidja 4,  Samir Benayache 5,  Artur M S Silva 6
Affiliations

Affiliations

  • 1 Campus de Santiago, Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal. [email protected].
  • 2 Unité de Recherche et Valorisation des Ressources Naturelles, Molécules Bioactives et Analyse Physico-chimiques et Biologiques, Université des Frères Mentouri Constantine 1, Constantine, Algeria. [email protected].
  • 3 Campus de Santiago, Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal. [email protected].
  • 4 Unité de Recherche et Valorisation des Ressources Naturelles, Molécules Bioactives et Analyse Physico-chimiques et Biologiques, Université des Frères Mentouri Constantine 1, Constantine, Algeria. [email protected].
  • 5 Unité de Recherche et Valorisation des Ressources Naturelles, Molécules Bioactives et Analyse Physico-chimiques et Biologiques, Université des Frères Mentouri Constantine 1, Constantine, Algeria. [email protected].
  • 6 Campus de Santiago, Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal. [email protected].
PMID: 29861483 DOI: 10.3390/molecules23061285
Abstract

The phenolic profile of Scabiosa stellata L., a species used in Moroccan traditional medicine, is disclosed. To obtain that profile the species extract was analyzed by ultra-high-performance chromatography coupled to photodiode-array detection and electrospray ionization/ion trap mass spectrometry (UHPLC-DAD-ESI/MSn). Twenty-five phenolic compounds were identified from which isoorientin and 4-O-caffeoylquinic acid can be highlighted because they are the major ones. The antioxidant activity was significantly controlled by the fraction type, with the n-butanol fraction showing the highest antioxidant activity (FRS50 = 64.46 µg/mL in the DPPH assay, FRS50 = 27.87 µg/mL in the ABTS assay and EC50 = 161.11 µg/mL in the reducing power assay). A phytochemical study of the n-butanol fraction was performed, and some important flavone glycosides were isolated. Among them the tamarixetin derivatives-the less common ones-can be emphasized. This phytochemical study and polyphenolic profile can be correlated with S. stellata extracts in vitro antioxidant activity. Moreover, it can be regarded as an evidence of its medicinal use and can incentivize its consumption.

Keywords

NMR; Scabiosa stellata L.; UHPLC-MS; antioxidant activity; flavone glycosides; phenolic profile.

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