2. Academic Validation
  3. Two new triterpenoids with antimicrobial activity from the leaves and twigs of Orophea yunnanensis

Two new triterpenoids with antimicrobial activity from the leaves and twigs of Orophea yunnanensis

  • Nat Prod Res. 2019 Dec;33(24):3472-3477. doi: 10.1080/14786419.2018.1481843.
Wei Zhao 1,  Xiao-Wei Gong 1,  Yuan-Xing Duan 1,  Ji Yang 1,  Xia Wu 2,  Xian-Jun Jiang 3,  Xiao-Hua Xu 3,  Yong-Kuan Chen 1,  Liu Yang 1,  Fei Wang 3,  Xiao-Long Yang 2
Affiliations

Affiliations

  • 1 Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd , Kunming , China.
  • 2 Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University , Chongqing , P. R. China.
  • 3 BioBioPha Co., Ltd. , Kunming , China.
PMID: 29882434 DOI: 10.1080/14786419.2018.1481843
Abstract

Two new triterpenoids, 3-O-(4',5'-dihydroxybenzoyl)-lup-20(29)-en (1) and 3-O-(6'-desmethysyringyl)-13α-methyl-27-norolean-14-en-3β-ol (2), were isolated from the leaves and twigs of Orophea yunnanensis. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data. Compounds 1 and 2 exhibited the moderate inhibitory activity against Sclerotinia sclerotiorum, Ceratocystis fimbriata and Verticillium dahliae Kleb with MIC values from 50 to 25 μg/mL, and also displayed the weak activity selectively against tested bacteria strains with MIC values from 100 to 50 μg/mL.

Keywords

antibacterial activity; antifungal activity; triterpenoids.

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