2. Academic Validation
  3. Two neolignans from Penthorum Chinense and their antiproliferative activities

Two neolignans from Penthorum Chinense and their antiproliferative activities

  • Nat Prod Res. 2020 Jun;34(11):1515-1520. doi: 10.1080/14786419.2018.1517261.
Doudou Huang 1,  Zhiying Dong 1,  Lei Sun 1,  Wansheng Chen 2,  Lianna Sun 1
Affiliations

Affiliations

  • 1 Department of TCM Processing, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.
  • 2 Department of Pharmacy, Changzheng Hospital Second Military Medical University, Shanghai, P.R. China.
PMID: 30388890 DOI: 10.1080/14786419.2018.1517261
Abstract

Chemical investigation of Penthorum chinense resulted in the isolation of two neolignans (1 and 2) together with two known compounds (3 and 4). The structures of compounds 1 and 2 were determined by interpretation of spectroscopic data, and absolute configurations were made based on electronic circular dichroism (ECD). All compounds were evaluated for their antiproliferative activity on hepatic stellate T6 cells (HSC-T6 cells), and 1 and 2 showed moderate activity with IC50 values of 15.3 and 10.1 μM, respectively.

Keywords

ECD experiment; Penthorum Chinense; neolignans.

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