2. Academic Validation
  3. New naphtoquinones derivatives from the edible bulbs of Eleutherine americana and their protective effect on the injury of human umbilical vein endothelial cells

New naphtoquinones derivatives from the edible bulbs of Eleutherine americana and their protective effect on the injury of human umbilical vein endothelial cells

  • Fitoterapia. 2019 Jan:132:46-52. doi: 10.1016/j.fitote.2018.11.009.
Deli Chen 1,  Jing Qiao 2,  Zhaocui Sun 3,  Yangyang Liu 1,  Zhonghao Sun 3,  Nailiang Zhu 3,  Xudong Xu 3,  Junshan Yang 3,  Guoxu Ma 4
Affiliations

Affiliations

  • 1 Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China.
  • 2 Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China.
  • 3 Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China.
  • 4 Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences, Peking Union Medical College, Haikou 570311, China; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China. Electronic address: [email protected].
PMID: 30496808 DOI: 10.1016/j.fitote.2018.11.009
Abstract

Seven new naphthoquinone derivatives, named eleutherins A-G (1-7), were isolated from the edible bulbs of Eleutherine americana (Hong-Cong), which belongs to the Iridaceae family. Their structures were elucidated on the basis of spectroscopic analysis including high-resolution-electron spray ionization-mass spectrometry (HR-ESI-MS) and 1D and 2D nuclear magnetic resonance (NMR) techniques. The absolute configurations of compounds 1-4 were determined by experimental and calculated data. Additionally, a hypothetical biosynthetic pathway of 1-7 was postulated. All the isolates were evaluated for their protective effect against the injury of human umbilical vein endothelial cells (HUVECs) in vitro. Eleutherins A and B (1-2) showed a potential protective effect on microvessels.

Keywords

Biosynthetic pathway; Eleutherine americana; HUVECs; Iridaceae family; Naphthoquinone derivatives.

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