2. Academic Validation
  3. A new flavanol from the roots of Daphne genkwa

A new flavanol from the roots of Daphne genkwa

  • J Asian Nat Prod Res. 2019 Dec;21(12):1215-1220. doi: 10.1080/10286020.2018.1530222.
Rui Wang 1,  Ling Tong 1,  Cai-Yun Liu 1,  Cong Guo 1
Affiliations

Affiliation

  • 1 Key Laboratory of Biochemistry and Molecular Biology in Universities of Shandong Province, Weifang University, Weifang 261061, China.
PMID: 30593256 DOI: 10.1080/10286020.2018.1530222
Abstract

The phytochemical investigation of the roots of Daphne genkwa yielded six secondary metabolites, including a new flavanol derivative, (2R, 3S)-5,7,4'-trihydroxy-8-methoxycarbonylflavanol (1), and five known compounds (2-6). The molecular structures of the isolated constituents were elucidated on the basis of extensive spectroscopic analysis, including UV, IR, NMR, and MS, and comparison with literature data. Furthermore, the cytotoxic activity of 1 and 2 against A549, HL-60, SMMC-7721, MCF-7, and SW480 cell lines was also described.

Keywords

Daphne genkwa; Thymelaeaceae; cytotoxic activity; flavanol; structure.

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