2. Academic Validation
  3. The lysosome as a cellular centre for signalling, metabolism and quality control

The lysosome as a cellular centre for signalling, metabolism and quality control

  • Nat Cell Biol. 2019 Feb;21(2):133-142. doi: 10.1038/s41556-018-0244-7.
Rosalie E Lawrence 1 2,  Roberto Zoncu 3 4
Affiliations

Affiliations

  • 1 Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA.
  • 2 The Paul F. Glenn Center for Aging Research, University of California at Berkeley, Berkeley, CA, USA.
  • 3 Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA. [email protected].
  • 4 The Paul F. Glenn Center for Aging Research, University of California at Berkeley, Berkeley, CA, USA. [email protected].
PMID: 30602725 DOI: 10.1038/s41556-018-0244-7
Abstract

Long known as terminal degradation stations, lysosomes have emerged as sophisticated signalling centres that govern cell growth, division and differentiation. Lysosomes interface physically and functionally with other organelles, and the master regulator mechanistic target of rapamycin complex 1 kinase is activated on lysosomes in response to nutrient and growth factor inputs. Lysosomes also enable Autophagy, a 'self-eating' process essential for quality control and stress adaptation. Faulty execution of lysosomal growth and catabolic programmes drives Cancer, neurodegeneration and age-related diseases.

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