2. Academic Validation
  3. New Anti-inflammatory Flavonol Glycosides from Lindera akoensis Hayata

New Anti-inflammatory Flavonol Glycosides from Lindera akoensis Hayata

  • Molecules. 2019 Feb 4;24(3):563. doi: 10.3390/molecules24030563.
Chung-Ping Yang 1 2 3,  Pei-Hsin Shie 4 5 6,  Guan-Jhong Huang 7,  Shih-Chang Chien 8,  Yueh-Hsiung Kuo 9 10 11 12
Affiliations

Affiliations

  • 1 Key Laboratory of Preventive Veterinary Medicine and Biotechnology, Longyan University,Longyan 364012, China. [email protected].
  • 2 Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases andBiotechnology, Longyan University, Longyan 364012, China. [email protected].
  • 3 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University,Taichung 404, Taiwan. [email protected].
  • 4 Key Laboratory of Preventive Veterinary Medicine and Biotechnology, Longyan University,Longyan 364012, China. [email protected].
  • 5 Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases andBiotechnology, Longyan University, Longyan 364012, China. [email protected].
  • 6 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University,Taichung 404, Taiwan. [email protected].
  • 7 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University,Taichung 404, Taiwan. [email protected].
  • 8 The Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, Taiwan. [email protected].
  • 9 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University,Taichung 404, Taiwan. [email protected].
  • 10 Department of Biotechnology, Asia University, Taichung 413, Taiwan. [email protected].
  • 11 Chinese Medicine Research Center, China Medical University, Taichung 404, Taiwan. [email protected].
  • 12 Research Center for Chinese Herbal Medicine, China Medical University, Taichung 404, Taiwan. [email protected].
PMID: 30720720 DOI: 10.3390/molecules24030563
Abstract

Inflammation is related to many diseases. Lindera akoensis Hayata was often used in folktherapy in Taiwan for inflammation. In this study, three new flavonol acyl glycosides, namelykaempferol-3-O--D-4",6"-di-(E)-p-coumaroylglucoside (1), 3"-(E)-p-coumaroylafzelin (2) and 40-Omethyl-2",4"-di-(E)-p-coumaroylquercitrin (3), and three components, 3-dodecyl-4-hydroxy-5-methyldihydrofuran-2-one (4), 2-acetoxyclovan-9-ol (5), (1,4,6)-trihydroxyeudesmane(6) that were isolated from the natural product for the first time were obtained along with 25 knowncompounds from L. akoensis. Their structures were determined by comprehensive spectroscopicanalyses (1D and 2D NMR, EI-, ESI- and HRESI-MS). The ability of 1 to decrease the LPS-stimulatedproduction of nitrite in RAW264.7 cell was evaluated, showing an IC50 value of 36.3 ± 3.2 μM.This result supports the value of L. akoensis as a traditional medicine resource.

Keywords

Lindera akoensis; anti-inflammatory; flavonol glycoside.

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