2. Academic Validation
  3. The TAAR5 agonist α-NETA causes dyskinesia in mice

The TAAR5 agonist α-NETA causes dyskinesia in mice

  • Neurosci Lett. 2019 Jun 21:704:208-211. doi: 10.1016/j.neulet.2019.04.028.
Aleksander A Aleksandrov 1,  Nadezhda V Polyakova 1,  Ekaterina P Vinogradova 1,  Raul R Gainetdinov 2,  Veronika M Knyazeva 3
Affiliations

Affiliations

  • 1 Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.
  • 2 Institute of Translational Biomedicine and Saint Petersburg University Hospital, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia.
  • 3 Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia. Electronic address: [email protected].
PMID: 30986441 DOI: 10.1016/j.neulet.2019.04.028
Abstract

It is known that trace amine-associated receptor 5 (TAAR5) is expressed in various regions of the central nervous system. However, very limited information is available on the behavioral effects of TAAR5 activation and the TAAR5 functional role, in general. We studied the effect of TAAR5 agonist (2-(alpha-naphthoyl) ethyltrimethylammonium iodide) systemic administration on animal behavior. The study was performed on male C57BL/6 mice. It was observed that α-NETA in 10 mg/kg dose caused specific impairment of motor behavior, similar to the manifestations of tardive dyskinesia in humans. It can be assumed that trace amines and TAAR5 may be involved in the human tardive dyskinesia pathogenesis.

Keywords

Dyskinesia; TAAR5; Tardive dyskinesia; Trace amine-associated receptors; Trace amines; α-NETA.

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