2. Academic Validation
  3. Sesquiterpenes from an Eastern African Medicinal Mushroom Belonging to the Genus Sanghuangporus

Sesquiterpenes from an Eastern African Medicinal Mushroom Belonging to the Genus Sanghuangporus

  • J Nat Prod. 2019 May 24;82(5):1283-1291. doi: 10.1021/acs.jnatprod.8b01086.
Tian Cheng 1,  Clara Chepkirui 1,  Cony Decock 2,  Josphat Clement Matasyoh 3,  Marc Stadler 1
Affiliations

Affiliations

  • 1 Department of Microbial Drugs , Helmholtz Centre for Infection Research (HZI), and German Centre for Infection Research (DZIF) , Partner Site Hannover/Braunschweig, Inhoffenstrasse 7 , 38124 Braunschweig , Germany.
  • 2 Mycothéque de l'Universite Catholique de Louvain (BCCM/MUCL) , Place Croix du Sud 3 , B-1348 Louvain-la-Neuve , Belgium.
  • 3 Department of Chemistry, Faculty of Sciences , Egerton University , P.O. Box 536, 20115 , Njoro , Kenya.
PMID: 31001977 DOI: 10.1021/acs.jnatprod.8b01086
Abstract

During the course of searching for new anti-infective and Other biologically active secondary metabolites from Kenyan basidiomycetes, 13 previously undescribed metabolites, (6 R,7 S,10 R)-7,10-epoxy-7,11-dimethyldodec-1-ene-6,11-diol (1) and 12 Sesquiterpenes named elgonenes A-L (2-13), and the known compound P-coumaric acid (14) were isolated from a basidiomycete collected in Mount Elgon Natural Reserve. The producing organism represents a new species of the genus Sanghuangporus, which is one of the segregates of the important traditional Asian medicinal mushrooms that were formerly known as the " Inonotus linteus" complex. The structure elucidation of compounds 1-13, based on 2D NMR spectroscopy, high-resolution mass spectrometry, and Other spectral methods, and their Antibacterial, Antifungal, and cytotoxic activities are reported.

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