2. Academic Validation
  3. Raistrickindole A, an Anti-HCV Oxazinoindole Alkaloid from Penicillium raistrickii IMB17-034

Raistrickindole A, an Anti-HCV Oxazinoindole Alkaloid from Penicillium raistrickii IMB17-034

  • J Nat Prod. 2019 May 24;82(5):1391-1395. doi: 10.1021/acs.jnatprod.9b00259.
Jiao Li 1,  Yuanyuan Hu 1,  Xiaomeng Hao 1,  Jiali Tan 1,  Fang Li 1,  Xinran Qiao 1,  Shuzhen Chen 1,  Chunling Xiao 1,  Minghua Chen 1,  Zonggen Peng 1,  Maoluo Gan 1
Affiliations

Affiliation

  • 1 Institute of Medicinal Biotechnology , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.
PMID: 31013089 DOI: 10.1021/acs.jnatprod.9b00259
Abstract

Raistrickindole A (1), a new indole diketopiperazine alkaloid containing an unusual pyrazino[1',2':2,3][1,2]oxazino[6,5- b]indole tetraheterocyclic ring system, a new benzodiazepine derivative, raistrickin (2), and the known haenamindole (3) and sclerotigenin (4) were isolated from the marine-derived fungus Penicillium raistrickii IMB17-034. Their structures were elucidated by extensive spectroscopic analyses and TDDFT calculations of the NMR and ECD data. Compounds 1 and 2 showed inhibitory activities against the hepatitis C virus.

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