Bioactive Diterpenoids from the Stems of Euphorbia antiquorum

J Nat Prod. 2019 Jun 28;82(6):1634-1644. doi: 10.1021/acs.jnatprod.9b00134.

Yue Liang ¹, Lijun An ¹, Zhaoyu Shi ¹, Xuke Zhang ¹, Chunfeng Xie ¹, Muhetaer Tuerhong ², Zhaohui Song ³, Yasushi Ohizumi ⁴, Dongho Lee ⁵, Ling Shuai ¹, Jing Xu ¹, Yuanqiang Guo ¹ ⁶

Affiliations

1 State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Tianjin 300350 , People's Republic of China.
2 College of Chemistry and Environmental Sciences , Kashgar University , Kashgar 844000 , People's Republic of China.
3 State Key Laboratory of Core Technology in Innovative Chinese Medicine , Tasly Pharmaceutical Group Co., Ltd. , Tianjin 300410 , People's Republic of China.
4 Tohoku Fukushi University , Sendai 989-3201 , Japan.
5 College of Life Sciences and Biotechnology , Korea University , Seoul 02841 , Republic of Korea.
6 State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , Guangxi Normal University , Guilin 541004 , People's Republic of China.

PMID: 31180680 DOI: 10.1021/acs.jnatprod.9b00134

Abstract

A total of 18 Diterpenoids, including 10 new analogues (1-10), were isolated from Euphorbia antiquorum. The structures were characterized by spectroscopic techniques, and circular dichroism data analysis was adopted to confirm the absolute configurations of 1-10. Compounds 1-9 were classified as ent-atisane Diterpenoids, and 10 was assigned as an ent-kaurane diterpenoid. The biological evaluation of nitric oxide (NO) production inhibition was conducted, and all of these isolates showed the property of inhibiting NO generation in lipopolysaccharide-induced BV-2 cells. Further research on molecular docking disclosed the affinities between the Diterpenoids obtained and inducible nitric oxide synthase.

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