2. Academic Validation
  3. A new demethyl abietane diterpenoid from the roots of Tripterygium wilfordii

A new demethyl abietane diterpenoid from the roots of Tripterygium wilfordii

  • Nat Prod Res. 2020 Nov;34(21):3094-3100. doi: 10.1080/14786419.2019.1610749.
Peng Li 1 2,  Shao-Xin Shen 2,  Ling-Xue Liu 2,  Jian-Hua Xu 2,  Xin-Hua Ma 1,  Dong-Mei Shi 1,  Zhi-Qiang Zhang 2
Affiliations

Affiliations

  • 1 Department of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, P. R. China.
  • 2 Fujian Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, P. R. China.
PMID: 31230492 DOI: 10.1080/14786419.2019.1610749
Abstract

A new demethyl abietane diterpenoid, Triptotin K (3) together with three known compounds, friedelin (1), canophyllal (2), and triptonoterpene (4) were isolated from the roots of Tripterygium wilfordii Hook. f. by silica gel column and preparative high performance liquid chromatography. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Triptotin K showed cytotoxic activities against KB, KBv200, HepG2, and MCF-7/ADM cells lines with IC50 values of 29.88, 36.50, 39.55, and 41.38 μM, respectively.

Keywords

Tripterygium wilfordii; cytotoxicity; diterpenoids; triterpenes.

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