2. Academic Validation
  3. The Chemistry and Biology of Cyclophostin, the Cyclipostins and Related Compounds

The Chemistry and Biology of Cyclophostin, the Cyclipostins and Related Compounds

  • Molecules. 2019 Jul 16;24(14):2579. doi: 10.3390/molecules24142579.
Christopher D Spilling 1
Affiliations

Affiliation

  • 1 Department of Chemistry & Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, MO 63121, USA. [email protected].
PMID: 31315184 DOI: 10.3390/molecules24142579
Abstract

Cyclophostin, the cyclipostins and the salinipostins are structurally related cyclic enolphosphate Natural Products. This mini review describes their isolation, synthesis and biological activities. In addition, the synthesis and biological activities of monocyclic enolphosphate and mono and bicyclic enolphosphonate analogs are presented.

Keywords

bicyclic; cyclipostins; cyclophostin; enolphosphate; enolphosphonate; inhibitor; lipase; monocyclic.

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