An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid

Molecules. 2019 Jul 24;24(15):2678. doi: 10.3390/molecules24152678.

Dai-Hung Ngo ¹, Thanh Sang Vo ²

Affiliations

1 Faculty of Natural Sciences, Thu Dau Mot University, Thu Dau Mot City 820000, Vietnam.
2 NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam. [email protected].

PMID: 31344785 DOI: 10.3390/molecules24152678

Abstract

Gamma-aminobutyric acid (Gaba) is a non-proteinogenic amino acid that is widely present in Microorganisms, Plants, and vertebrates. So far, Gaba is well known as a main inhibitory neurotransmitter in the central nervous system. Its physiological roles are related to the modulation of synaptic transmission, the promotion of neuronal development and relaxation, and the prevention of sleeplessness and depression. Besides, various pharmaceutical properties of Gaba on non-neuronal peripheral tissues and organs were also reported due to anti-hypertension, anti-diabetes, anti-cancer, antioxidant, anti-inflammation, anti-microbial, anti-allergy, hepato-protection, reno-protection, and intestinal protection. Therefore, Gaba may be considered as potential alternative therapeutics for prevention and treatment of various diseases. Accordingly, this updated review was mainly focused to describe the pharmaceutical properties of Gaba as well as emphasize its important role regarding human health.

Keywords

Gaba; Gaba-rich product; anti-hypertension; bioactivity; health benefit.

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