Synthetic routes and structure-activity relationships (SAR) of anti-HIV agents: A key review

Eur J Med Chem. 2019 Nov 1:181:111566. doi: 10.1016/j.ejmech.2019.111566.

Yu-Mei Huang ¹, Njud S Alharbi ², Bing Sun ³, C S Shantharam ⁴, K P Rakesh ⁵, Hua-Li Qin ⁶

Affiliations

1 Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China.
2 Biotechnology Research Group, Deportment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
3 Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China. Electronic address: [email protected].
4 Department of Chemistry, Pooja Bhagavath Memorial Mahajana Education Centre, Mysuru, 570016, Karnataka, India.
5 Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China. Electronic address: [email protected].
6 Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China. Electronic address: [email protected].

PMID: 31401538 DOI: 10.1016/j.ejmech.2019.111566

Abstract

The worldwide increase of AIDS, an epidemic Infection in constant development has an essential and still requires potent antiretroviral chemotherapeutic agents for reducing the integer of deaths caused by HIV. Thus, there is an urgent need for new anti-HIV drug candidates with increased strength, new targets, superior pharmacokinetic properties, and compact side effects. From this viewpoint, we first review present strategies of anti-HIV drug innovation and the synthesis of heterocyclic or natural compound as anti-HIV agents for facilitating the development of more influential and successful anti-HIV agents.

Keywords

Anti-HIV; Molecular docking; SAR; Synthesis.

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