2. Academic Validation
  3. Germacrane-type sesquiterpenoids with cytotoxic activity from Sigesbeckia orientalis

Germacrane-type sesquiterpenoids with cytotoxic activity from Sigesbeckia orientalis

  • Bioorg Chem. 2019 Nov;92:103196. doi: 10.1016/j.bioorg.2019.103196.
Na Liu 1,  Cong Wu 1,  Jin-Hai Yu 1,  Kong-Kai Zhu 1,  Mei-Na Song 1,  Feng-Ying Yang 1,  Run-Liang Feng 1,  Yu-Ying Zhang 1,  Wen-Qiang Chang 2,  Hua Zhang 3
Affiliations

Affiliations

  • 1 School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China.
  • 2 Key Lab of Chemical Biology of Ministry of Education, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
  • 3 School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. Electronic address: [email protected].
PMID: 31445194 DOI: 10.1016/j.bioorg.2019.103196
Abstract

Eleven new highly oxygenated germacrane-type sesquiterpenoids (1-11) and 16 known analogues (12-27) were isolated from the aerial parts of Sigesbeckia orientalis. Their structures, including absolute configurations, were determined by comprehensive spectroscopic methods especially NMR and ECD analyses. Compounds 13, 21 and 23 possessing an 8-methacryloxy group showed stronger in vitro cytotoxicity against human A549 and MDA-MB-231 Cancer cell lines than other co-metabolites, with IC50 values ranging from 6.02 to 10.77 μM comparable to the positive control adriamycin.

Keywords

Cytotoxicity; Germacrane; Sesquiterpenoids; Sigesbeckia orientalis.

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