2. Academic Validation
  3. Practical Method for Preparation of ( S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution

Practical Method for Preparation of ( S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution

  • ACS Omega. 2019 Jul 9;4(7):11844-11851. doi: 10.1021/acsomega.9b01537.
Haibo Mei 1,  Jianlin Han 1,  Ryosuke Takeda 2 3,  Tsubasa Sakamoto 2,  Toshio Miwa 2,  Yutaka Minamitsuji 2,  Hiroki Moriwaki 2,  Hidenori Abe 2,  Vadim A Soloshonok 3 4
Affiliations

Affiliations

  • 1 College of Chemical Engineering Nanjing Forestry University, Nanjing 210037, China.
  • 2 Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
  • 3 Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, San Sebastián 20018, Spain.
  • 4 IKERBASQUE-Basque Foundation for Science, María Díaz de Haro 3, Plaza Bizkaia, Bilbao 48013, Spain.
PMID: 31460294 DOI: 10.1021/acsomega.9b01537
Abstract

This work reports an operationally convenient ∼20 g scale synthesis of (S)-2-amino-5,5,5-trifluoropentanoic acid and its Fmoc-derivative via dynamic kinetic resolution of the corresponding racemate.

Figures
Products