2. Academic Validation
  3. Review: Ewing Sarcoma Predisposition

Review: Ewing Sarcoma Predisposition

  • Pathol Oncol Res. 2020 Oct;26(4):2057-2066. doi: 10.1007/s12253-019-00765-3.
Pablo Gargallo 1,  Yania Yáñez 2,  Antonio Juan 3,  Vanessa Segura 2,  Julia Balaguer 3,  Bárbara Torres 3,  Silves Oltra 4 5,  Victoria Castel 3,  Adela Cañete 3
Affiliations

Affiliations

  • 1 Clinical and Translational Oncology Research Group, La Fe Hospital, Av. Fernando Abril Martorell 106 Postal Code, 46026, Valencia, Spain. [email protected].
  • 2 Clinical and Translational Oncology Research Group, La Fe Hospital, Av. Fernando Abril Martorell 106 Postal Code, 46026, Valencia, Spain.
  • 3 Pediatric Oncology and Hematology Unit, La Fe Hospital, Valencia, Spain.
  • 4 Genetics Unit, La Fe Hospital, Valencia, Spain.
  • 5 Genetics Department, Valencia University, Valencia, Spain.
PMID: 31656020 DOI: 10.1007/s12253-019-00765-3
Abstract

Ewing sarcoma is a rare tumor developed in bone and soft tissues of children and teenagers. This entity is biologically led by a chromosomal translocation, typically including EWS and FLI1 genes. Little is known about Ewing sarcoma predisposition, although the role of environmental factors, ethnicity and certain polymorphisms on Ewing sarcoma susceptibility has been studied during the last few years. Its prevalence among Cancer predisposition syndromes has also been thoroughly examined. This review summarizes the available evidence on predisposing factors involved in Ewing sarcoma susceptibility. On the basis of these data, an integrated approach of the most influential factors on Ewing sarcoma predisposition is proposed.

Keywords

Cancer predisposition; Ewing sarcoma; Genetic susceptibility; Polymorphism.

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