2. Academic Validation
  3. Two new biflavanoids from Selaginella trichoclada Alsto

Two new biflavanoids from Selaginella trichoclada Alsto

  • Nat Prod Res. 2021 Oct;35(20):3410-3416. doi: 10.1080/14786419.2019.1700506.
Yang Xie 1,  Ping-Sheng Xu 1,  Kang-Ping Xu 2,  Zhen-Xing Zou 2,  Gan Zhou 1,  Dai Li 1,  Dan Li 1,  Xiao-Min Li 1,  Jing Li 1,  Gui-Shan Tan 1 2
Affiliations

Affiliations

  • 1 Xiangya Hospital of Central South University, Changsha, PR China.
  • 2 Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China.
PMID: 31841035 DOI: 10.1080/14786419.2019.1700506
Abstract

Two new robustaflavones, (±)-trichocladabiflavone A (1) and uncinatabiflavone E (2), along with seven known biflavanoids (3-9) were isolated from the 70% EtOH extract of Selaginella trichoclada. Their structures and absolute configurations were established by extensive spectroscopic and circular dichroism (CD) analyses. Compound 1 was resoluted into optically pure enantiomers (+)-1 and (-)-1 by chiral-phase HPLC. Moreover, compounds 1 and 2 exhibited moderate cytotoxicity against A549 and HepG2 human Cancer cell lines.

Keywords

Selaginella trichoclada; cytotoxicity; robustaflavone.

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