2. Academic Validation
  3. Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU

Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU

  • J Org Chem. 2020 Feb 7;85(3):1764-1768. doi: 10.1021/acs.joc.9b03280.
Kate J McKnelly 1,  William Sokol 1,  James S Nowick 1
Affiliations

Affiliation

  • 1 Department of Chemistry & Department of Pharmaceutical Sciences , University of California, Irvine , Irvine , California 92697 , United States.
PMID: 31849224 DOI: 10.1021/acs.joc.9b03280
Abstract

Peptide coupling agents pose a special hazard because they are immune sensitizers. Here, we present a case study of anaphylaxis induced by three uronium coupling agents, HATU, HBTU, and HCTU, as a cautionary note for researchers who handle peptide coupling agents frequently. We also include recommendations for handling coupling agents more safely in the research laboratory.

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