2. Academic Validation
  3. The role of lncRNA MALAT1 in cardiovascular disease

The role of lncRNA MALAT1 in cardiovascular disease

  • IUBMB Life. 2020 Mar;72(3):334-342. doi: 10.1002/iub.2210.
Youyou Yan 1 2,  Dandan Song 3,  Xianjing Song 1,  Chunli Song 1
Affiliations

Affiliations

  • 1 Department of Cardiology, Second Hospital of Jilin University, Changchun, China.
  • 2 Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, China.
  • 3 Department of Clinical Laboratory, Second Hospital of Jilin University, Changchun, China.
PMID: 31856403 DOI: 10.1002/iub.2210
Abstract

Cardiovascular Disease (CVD) is the first leading cause of death worldwide. Understanding the molecular mechanism of signaling pathways involved in pathology of CVD is benefit for targeted therapeutics. Recently, long non-coding RNAs (lncRNAs) are found and involved in regulation of pathology of CVD at different levels. Among them, MALAT1 attracted more attention as it was profoundly expressed in endothelial cells or cardiomyocytes in response to the risk factors of CVD, such as hypoxia, high glucose, cytokine, and oxidative stress. In this review, we summarize recent progresses in research on the molecular mechanism of MALAT1 on regulating the pathophysiological processes of CVD as well as its potential therapeutic applications.

Keywords

MALAT1; cardiovascular disease; lncRNAs.

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