2. Academic Validation
  3. Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana

Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana

  • Chin J Nat Med. 2019 Dec;17(12):953-962. doi: 10.1016/S1875-5364(19)30118-9.
Yuan Wang 1,  Jing Lin 1,  Qi Wang 1,  Kun Shang 1,  De-Bing Pu 1,  Rui-Han Zhang 1,  Xiao-Li Li 1,  Xiao-Chang Dai 1,  Xing-Jie Zhang 2,  Wei-Lie Xiao 3
Affiliations

Affiliations

  • 1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
  • 2 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: [email protected].
  • 3 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: [email protected].
PMID: 31882051 DOI: 10.1016/S1875-5364(19)30118-9
Abstract

Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane Diterpenoids, cathayanalactones A-F (1-6), together with seven analogues (7-13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

Keywords

Anti-inflammatory activity; Callicarpa cathayana; Clerodane diterpenoids; Nitric oxide.

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