Cyclodextrin-based delivery systems for chemotherapeutic anticancer drugs: A review

Carbohydr Polym. 2020 Mar 15;232:115805. doi: 10.1016/j.carbpol.2019.115805.

Bingren Tian ¹, Shiyao Hua ², Jiayue Liu ³

Affiliations

1 College of Chemistry and Chemical Engineering, Xinjiang University, Urumchi 830001, China. Electronic address: [email protected].
2 School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
3 School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China. Electronic address: [email protected].

PMID: 31952603 DOI: 10.1016/j.carbpol.2019.115805

Abstract

Cancer is increasingly becoming a serious threat to human life and health. Therefore, the development of safe and effective therapeutic agents against the disease is of crucial significance. Cyclodextrins (CDs) are cyclic oligosaccharides obtained by the enzymatic hydrolysis of starch, and constitute a class of cyclic oligosaccharides with external hydrophilic and internal hydrophobic properties and have been used widely in Cancer therapy. Cyclodextrin has been extensively applied in nanomedicine therapy, gene therapy, cell therapy, immunotherapy, and chemotherapy. In this review, we summarize chemotherapy drugs for Cancer treatment, classify various CD-based drug delivery systems, and describe their chemotherapy release and Cancer treatment performance. In addition, current challenges and new opportunities for CD-based chemotherapeutic agents delivery systems are discussed.

Keywords

Cancer therapy; Conjugates; Cyclodextrin; Drug delivery; Inclusion complexes; Polymers.

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