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  3. Degradation of intracellular TGF-β1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events

Degradation of intracellular TGF-β1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events

  • Chem Commun (Camb). 2020 Mar 5;56(19):2881-2884. doi: 10.1039/c9cc08391j.
Yanqiao Feng 1,  Hui Su 1,  Yunzhi Li 1,  Chunxiang Luo 1,  Huiying Xu 1,  Youqiao Wang 1,  Haixia Sun 1,  Guohui Wan 1,  Binhua Zhou 2,  Xianzhang Bu 1
Affiliations

Affiliations

PMID: 32037404 DOI: 10.1039/c9cc08391j
Abstract

The first proteolysis targeting chimeras for the intracellular elimination of transforming growth factor-β1 (TGF-β1), which contributes to various diseases, are described. The appropriately designed DT-6 could efficiently degrade intracellular TGF-β1, and inhibit M2 macrophage induced epithelial to mesenchymal transition and invasive migration of Cancer cells.

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