2. Academic Validation
  3. Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

  • Nat Commun. 2020 Feb 28;11(1):1126. doi: 10.1038/s41467-020-14963-0.
Min Li  # 1 2 3,  Shuya Li  # 1,  Han Zhou 1,  Xinfeng Tang 1,  Yi Wu 1,  Wei Jiang 1,  Zhigang Tian 1,  Xuechang Zhou 3,  Xianzhu Yang 4,  Yucai Wang 5 6
Affiliations

Affiliations

  • 1 Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, 230027, Hefei, Anhui, China.
  • 2 Intelligent Nanomedicine Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, Anhui, China.
  • 3 College of Chemistry and Environmental Engineering, Shenzhen University, 518060, Shenzhen, Guangdong, China.
  • 4 Institutes for Life Sciences, School of Medicine and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, 510006, Guangzhou, China.
  • 5 Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, 230027, Hefei, Anhui, China. [email protected].
  • 6 Intelligent Nanomedicine Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, Anhui, China. [email protected].
  • # Contributed equally.
PMID: 32111847 DOI: 10.1038/s41467-020-14963-0
Abstract

The efficacy of nano-mediated drug delivery has been impeded by multiple biological barriers such as the mononuclear phagocyte system (MPS), as well as vascular and interstitial barriers. To overcome the abovementioned obstacles, we report a nano-pathogenoid (NPN) system that can in situ hitchhike circulating neutrophils and supplement photothermal therapy (PTT). Cloaked with bacteria-secreted outer membrane vesicles inheriting pathogen-associated molecular patterns of native bacteria, NPNs are effectively recognized and internalized by neutrophils. The neutrophils migrate towards inflamed tumors, extravasate across the blood vessels, and penetrate through the tumors. Then NPNs are rapidly released from neutrophils in response to inflammatory stimuli and subsequently taken up by tumor cells to exert Anticancer effects. Strikingly, due to the excellent targeting efficacy, cisplatin-loaded NPNs combined with PTT completely eradicate tumors in all treated mice. Such a nano-platform represents an efficient and generalizable strategy towards in situ cell hitchhiking as well as enhanced tumor targeted delivery.

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