1. Academic Validation
  2. Wood-Derived Hybrid Scaffold with Highly Anisotropic Features on Mechanics and Liquid Transport toward Cell Migration and Alignment

Wood-Derived Hybrid Scaffold with Highly Anisotropic Features on Mechanics and Liquid Transport toward Cell Migration and Alignment

  • ACS Appl Mater Interfaces. 2020 Apr 15;12(15):17957-17966. doi: 10.1021/acsami.0c00646.
Jinming Liu 1 Peng Yu 1 Dingqian Wang 1 Zhuoxin Chen 1 Qinke Cui 1 Bohan Hu 1 Dongyue Zhang 1 Yanyan Li 1 Hetao Chu 1 Jianshu Li 1
Affiliations

Affiliation

  • 1 College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
Abstract

Fantastic structures in nature have inspired much incredible research. Wood, a typical model of anisotropy and hierarchy, has been widely investigated for its mechanical properties and water extraction abilities, although applications in biological areas remain challenging. Delignified wood composite with in situ deposited hydroxyapatite (HAp) and infiltrated polycaprolactone (PCL) is hereby fabricated in an attempt to mimic natural bone. The inherent structure and properties of wood are carefully preserved during the fabrication, showing anisotropic mechanical properties in the radial direction (420 MPa) and longitudinal direction (20 MPa). In addition, it also performs directional liquid transport, effectively inducing the migration and alignment of cells to simulate the uniform seeding behavior of various cells in natural bone. Moreover, the synergistic effect of blended HAp and PCL largely promotes cell proliferation and osteogenic differentiation, providing a promising candidate for bone regeneration Materials.

Keywords

anisotropy; cell migration and alignment; liquid transport; scaffolds; wood.

Figures
Products