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  3. Emerging methods in therapeutics using multifunctional nanoparticles

Emerging methods in therapeutics using multifunctional nanoparticles

  • Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Jul;12(4):e1625. doi: 10.1002/wnan.1625.
Nahal Habibi 1,  Daniel F Quevedo 2,  Jason V Gregory 1,  Joerg Lahann 1 2 3 4
Affiliations

Affiliations

  • 1 Biointerfaces Institute, Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
  • 2 Biointerfaces Institute, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
  • 3 Biointerfaces Institute, Department of Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan, USA.
  • 4 Biointerfaces Institute, Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan, USA.
PMID: 32196991 DOI: 10.1002/wnan.1625
Abstract

Clinical translation of nanoparticle-based drug delivery systems is hindered by an array of challenges including poor circulation time and limited targeting. Novel approaches including designing multifunctional particles, cell-mediated delivery systems, and fabrications of protein-based nanoparticles have gained attention to provide new perspectives to current drug delivery obstacles in the interdisciplinary field of nanomedicine. Collectively, these nanoparticle devices are currently being investigated for applications spanning from drug delivery and Cancer therapy to medical imaging and immunotherapy. Here, we review the current state of the field, highlight opportunities, identify challenges, and present the future directions of the next generation of multifunctional nanoparticle drug delivery platforms. This article is categorized under: Biology-Inspired Nanomaterials > Protein and Virus-Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

Keywords

blood-brain barrier; cancer therapy; cellular hitchhiking; clinical trials; drug delivery; multifunctional nanoparticles; nanomedicine; protein nanoparticles.

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