2. Academic Validation
  3. Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview

Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview

  • Eur J Med Chem. 2020 May 15:194:112260. doi: 10.1016/j.ejmech.2020.112260.
Subha Mondal 1,  Nilanjan Adhikari 1,  Suvankar Banerjee 1,  Sk Abdul Amin 1,  Tarun Jha 2
Affiliations

Affiliations

  • 1 Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, P. O. Box 17020, Jadavpur University, Kolkata, 700032, India.
  • 2 Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, P. O. Box 17020, Jadavpur University, Kolkata, 700032, India. Electronic address: [email protected].
PMID: 32224379 DOI: 10.1016/j.ejmech.2020.112260
Abstract

Matrix Metalloproteinases (MMPs) are zinc dependent proteolytic metalloenzyme. MMP-9 is one of the most complex forms of Matrix Metalloproteinases. MMP-9 has the ability to degrade the extracellular matrix (ECM) components and has important role in the pathophysiological functions. Overexpression and dysregulation of MMP-9 is associated with various diseases. Thus, regulation and inhibition of MMP-9 is an important therapeutic approach for combating various diseases including Cancer. Inhibitors of MMP-9 can be used as Anticancer agents. Till date no selective MMP-9 inhibitors passed the clinical trials. In this review the structure, activation, function and inhibitors of MMP-9 are mainly focused. Some highly active and/or selective MMP-9 inhibitors have been discussed which may be helpful to explore the structural significance of MMP-9 inhibitors. This study may be useful to design new potent and selective MMP-9 inhibitors against Cancer in future.

Keywords

Cancer; Hydroxamate; MMP-9; MMP-9 inhibitor; Matrix metalloproteinase.

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