2. Academic Validation
  3. Mechanisms of immune escape in the cancer immune cycle

Mechanisms of immune escape in the cancer immune cycle

  • Int Immunopharmacol. 2020 Sep:86:106700. doi: 10.1016/j.intimp.2020.106700.
Sha Tang 1,  Qian Ning 2,  Ling Yang 1,  Zhongcheng Mo 3,  Shengsong Tang 4
Affiliations

Affiliations

  • 1 Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research & Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China; Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, Hunan University of Medicine, Huaihua 418000, China.
  • 2 Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, Hunan University of Medicine, Huaihua 418000, China.
  • 3 Institute of Basic Medical Sciences, College of Basic Medicine, Guilin Medical University, Guilin 541199, Guangxi, China.
  • 4 Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research & Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China; Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, Hunan University of Medicine, Huaihua 418000, China. Electronic address: [email protected].
PMID: 32590316 DOI: 10.1016/j.intimp.2020.106700
Abstract

Cancer is a critical issue globally with high incidence and mortality, imposing great burden on the society. Although great progress has been made in immunotherapy based on immune checkpoint, only a subset of patients responds to this treatment, suggesting that Cancer immune evasion is still a major barrier in current immunotherapy. There are a series of factors contributing to immune evasion despite in an immunocompetent environment. Given that these factors are involved in different steps of the Cancer immune cycle. In this review, we discuss the mechanisms of immune escape in each step of the Cancer immune cycle and then present therapeutic strategies for overcoming immune escape, with the potential to better understand the determinants of immune escape and make anti-tumor immunity more effective.

Keywords

Cancer immune cycle; Immune checkpoint; Immune escape; Immunotherapy.

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