Anticancer fungal natural products: Mechanisms of action and biosynthesis

Eur J Med Chem. 2020 Sep 15:202:112502. doi: 10.1016/j.ejmech.2020.112502.

Siwen Yuan ¹, Jannu Vinay Gopal ¹, Shuya Ren ¹, Litong Chen ¹, Lan Liu ², Zhizeng Gao ³

Affiliations

1 School of Marine Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
2 School of Marine Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, 519000, China.
3 School of Marine Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, 519000, China. Electronic address: [email protected].

PMID: 32652407 DOI: 10.1016/j.ejmech.2020.112502

Abstract

Many Fungal metabolites show promising Anticancer properties both in vitro and in animal models, and some synthetic analogs of those metabolites have progressed into clinical trials. However, currently, there are still no fungi-derived agents approved as Anticancer drugs. Two potential reasons could be envisioned: 1) lacking a clear understanding of their Anticancer mechanism of action, 2) unable to supply enough Materials to support the preclinical and clinic developments. In this review, we will summarize recent efforts on elucidating the Anticancer mechanisms and biosynthetic pathways of several promising Anticancer fungal natural products.

Keywords

Anticancer; Anticancer drug target; Biosynthesis; Fungal natural products; Mechanism of action.

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