2. Academic Validation
  3. Three 11,12-seco-tanshinone derivatives from the rhizomes of Salvia miltiorrhiza

Three 11,12-seco-tanshinone derivatives from the rhizomes of Salvia miltiorrhiza

  • J Asian Nat Prod Res. 2020 Oct;22(10):935-940. doi: 10.1080/10286020.2020.1799988.
Quan-Chang Gu 1,  Zhao-Kun Yin 1,  Zi-Ming Feng 1,  Jian-Shuang Jiang 1,  Xu Zhang 1,  Pei-Cheng Zhang 1,  Ya-Nan Yang 1
Affiliations

Affiliation

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Peking Union Medical College and Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
PMID: 32757770 DOI: 10.1080/10286020.2020.1799988
Abstract

Three new compounds named tanshinoic acid A (1), tanshinoic acid B (2), and tanshinoic acid C (3) were isolated from the rhizomes of Salvia miltiorrhiza, together with two known compounds methyl salvianolate A (4) and methyl salvianolate C (5). Their structures were determined on the basis of spectroscopic data (UV, IR, HRESIMS, 1 D and 2 D NMR). The in vitro assay indicated that 4 and 5 could improve the survived rate of cells on oxygen glucose deprivation (OGD) induced neurons damage model and glutamate-induced neurons damage model at a concentration of 10 μM. [Formula: see text].

Keywords

Salvia miltiorrhiza; neuro-protect; salvianolic acid; structure elucidation; tanshinone diterpene derivatives.

Figures
Products