2. Academic Validation
  3. Diverse Types of Diterpenoids with an Aromatized C Ring from the Twigs of Podocarpus imbricatus

Diverse Types of Diterpenoids with an Aromatized C Ring from the Twigs of Podocarpus imbricatus

  • J Nat Prod. 2020 Aug 28;83(8):2416-2424. doi: 10.1021/acs.jnatprod.0c00291.
Bin Zhou 1 2,  Yu-Hao Ren 1 2,  Ying-Shan Han 3,  Thibault Mesplède 3,  Jian-Min Yue 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
  • 2 University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China.
  • 3 McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.
PMID: 32786878 DOI: 10.1021/acs.jnatprod.0c00291
Abstract

An ethanol extract of the powdered twigs of Podocarpus imbricatus afforded 14 new Diterpenoids (1-14), which all share an aromatized C ring. These isolates belong to five diterpenoid types that include abietanes (1-3), semperviranes (4-9), totaranes (10-12), a C-17 norabietane (13), and an icetexane (14). Their structures were assigned mainly by analysis of the spectroscopic data, and the absolute configuration of 1 was determined by X-ray crystallography. A biosynthetic pathway for five of the biogenetically related types of Diterpenoids was proposed. Compound 7 showed moderate inhibitory activity against Zika virus with an IC50 value of 2.5 μM.

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