2. Academic Validation
  3. Isolation, reactivity, pharmacological activities and total synthesis of hispanolone and structurally related diterpenes from Labiatae plants

Isolation, reactivity, pharmacological activities and total synthesis of hispanolone and structurally related diterpenes from Labiatae plants

  • Bioorg Med Chem Lett. 2020 Nov 1;30(21):127498. doi: 10.1016/j.bmcl.2020.127498.
José L Marco 1
Affiliations

Affiliation

  • 1 Department of Natural Products (Institute of Organic Chemistry, CSIC), C/ Juan de la Cierva, 3, 28006 Madrid, Spain. Electronic address: [email protected].
PMID: 32818604 DOI: 10.1016/j.bmcl.2020.127498
Abstract

Hispanolone is a furolabdane diterpene isolated from Ballota hispanica, whose natural product chemistry has been summarized and updated here, including several aspects associated with the isolation, structure determination, hemisynthesis, total synthesis, and pharmacology, and related hispanolone Diterpenoids that have attracted the interest of different laboratories from diverse perspective and expertise in the last forty-two years.

Keywords

Ballota genus; Diterpenes; Hemisynthesis; Hispanolone; Isolation; Labiatae family; Natural products; Pharmacology; Reactivity; Total synthesis.

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