2. Academic Validation
  3. Anticandidal formyl phloroglucinol meroterpenoids: Biomimetic synthesis and in vitro evaluation

Anticandidal formyl phloroglucinol meroterpenoids: Biomimetic synthesis and in vitro evaluation

  • Bioorg Chem. 2020 Nov;104:104248. doi: 10.1016/j.bioorg.2020.104248.
Lin-Fang Zhong 1,  Zhi-Chun Shang 1,  Fu-Juan Sun 1,  Pan-Hu Zhu 1,  Yong Yin 1,  Ling-Yi Kong 2,  Ming-Hua Yang 3
Affiliations

Affiliations

  • 1 Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
  • 2 Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China. Electronic address: [email protected].
  • 3 Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China. Electronic address: [email protected].
PMID: 32916392 DOI: 10.1016/j.bioorg.2020.104248
Abstract

Inspired by the diversity-oriented synthesis, some novel formyl phloroglucinol meroterpenoids were synthesized via biomimetic synthesis using essential oils. Eight of them were demonstrated with good in vitro fungicidal activity against Candida albicans and C. glabrata. Compound c2 showed the best anticandidal ability that was powerfully comparable to fluconazole when testing against several strains in vitro. The antibiofilm activity was also found for the c2 treating group which was evidenced to block the hyphal elongation and filamentation of C. albicans. Therefore, compound c2 is a promising candidate for further antifungal-based structure modification.

Keywords

Antibiofilm activity; Anticandidal activity; Essential oil; Formyl phloroglucinol meroterpenoids.

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