2. Academic Validation
  3. Chemotherapy for the Management of Cerebral Metastases

Chemotherapy for the Management of Cerebral Metastases

  • Neurosurg Clin N Am. 2020 Oct;31(4):603-611. doi: 10.1016/j.nec.2020.06.009.
Chase H Foster 1,  Pooja Dave 2,  Jonathan H Sherman 3
Affiliations

Affiliations

  • 1 Department of Neurological Surgery, George Washington University Hospital, 2150 Pennsylvania Avenue, Northwest, Suite 7-420, Washington, DC 20037, USA.
  • 2 The GW School of Medicine & Health Sciences, 2150 Pennsylvania Avenue, Northwest, Suite 7-420, Washington, DC 20037, USA.
  • 3 West Virginia University, Eastern Division, 800 North Tennessee Avenue, Suite 104, Martinsburg, WV 25401, USA. Electronic address: [email protected].
PMID: 32921355 DOI: 10.1016/j.nec.2020.06.009
Abstract

Chemotherapy has played a minor role as adjuvant therapy in treatment of cerebral metastases from solid cancers. The blood-brain barrier and cerebral metastases' considerable machinery of self-preservation have been significant obstacles to delivery and efficacy of chemotherapy. However, several methods intended to surmount these challenges have arisen alongside advent of technology and with the development of targeted molecular therapies. Focused ultrasound and molecular Trojan horses represent two such novel means of increasing permeability of the blood-brain barrier to effector agents. Published data on efficacy of these targeted therapies remain mostly restricted to retrospective studies and phase II prospective clinical trials.

Keywords

Brain; Cerebral metastasis; Chemotherapy; Neurosurgery; Tumor.

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