2. Academic Validation
  3. The role of IL-22 in intestinal health and disease

The role of IL-22 in intestinal health and disease

  • J Exp Med. 2020 Feb 13;217(3):e20192195. doi: 10.1084/jem.20192195.
Mary Keir 1,  Tangsheng Yi 2,  Timothy Lu 3,  Nico Ghilardi 4
Affiliations

Affiliations

  • 1 Biomarker Discovery, Genentech, South San Francisco, CA
  • 2 Department of Immunology, Genentech, South San Francisco, CA
  • 3 Early Clinical Development, Genentech, South San Francisco, CA
  • 4 DiCE Molecules, South San Francisco, CA
PMID: 32997932 DOI: 10.1084/jem.20192195
Abstract

The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. In this review, we focus specifically on the role of IL-22 in the intestinal epithelium. We summarize recent advances in our understanding of how IL-22 regulates homeostasis and host defense, and we discuss the IL-22 pathway as a therapeutic target in diseases of the intestine, including inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and Cancer.

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