2. Academic Validation
  3. Transcriptional Regulation of Sphingosine Kinase 1

Transcriptional Regulation of Sphingosine Kinase 1

  • Cells. 2020 Nov 8;9(11):2437. doi: 10.3390/cells9112437.
Joseph Bonica 1,  Cungui Mao 2 3,  Lina M Obeid 1 2 3,  Yusuf A Hannun 1 2 3
Affiliations

Affiliations

  • 1 Department of Pharmacology, Stony Brook University, Stony Brook, NY 11794, USA.
  • 2 Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
  • 3 Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA.
PMID: 33171624 DOI: 10.3390/cells9112437
Abstract

Once thought to be primarily structural in nature, sphingolipids have become increasingly appreciated as second messengers in a wide array of signaling pathways. Sphingosine kinase 1, or SK1, is one of two sphingosine kinases that phosphorylate sphingosine into sphingosine-1-phosphate (S1P). S1P is generally pro-inflammatory, pro-angiogenic, immunomodulatory, and pro-survival; therefore, high SK1 expression and activity have been associated with certain inflammatory diseases and Cancer. It is thus important to develop an understanding of the regulation of SK1 expression and activity. In this review, we explore the current literature on SK1 transcriptional regulation, illustrating a complex system of transcription factors, cytokines, and even micro-RNAs (miRNAs) on the post transcriptional level.

Keywords

SK1; hypoxia; long non-coding RNA; microRNA; sphingosine kinase 1; transcription factor.

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