2. Academic Validation
  3. Glycosylated Phenols and an Unprecedented Diacid from the Saudi Plant Cissus rotundifolia

Glycosylated Phenols and an Unprecedented Diacid from the Saudi Plant Cissus rotundifolia

  • J Nat Prod. 2020 Nov 25;83(11):3298-3304. doi: 10.1021/acs.jnatprod.0c00597.
Jawaher Alqahtani 1 2,  Carmen Formisano 1,  Giuseppina Chianese 1,  Paolo Luciano 1,  Mariano Stornaiuolo 1,  Shagufta Perveen 2,  Orazio Taglialatela-Scafati 1
Affiliations

Affiliations

  • 1 Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
  • 2 Department of Pharmacognosy, College of Pharmacy, King Saud University. P.O. Box 22452, Riyadh 11495, Kingdom of Saudi Arabia.
PMID: 33176095 DOI: 10.1021/acs.jnatprod.0c00597
Abstract

Bioassay-guided investigation of the Saudi medicinal and edible plant Cissus rotundifolia yielded seven metabolites, including the new sucrose diester cissuxinoside (1) and the unprecedented cissoic acid (2), belonging to unusual classes of secondary metabolites. Their chemical structures were elucidated through a combination of HR-MS and NMR data. The absolute configuration of cissoic acid was assigned by comparison of experimental and TDDFT-calculated electronic circular dichroism spectra. In addition, three rare C-glycosyl Flavones (3-5) were fully characterized, and for 3 and 4 NMR data are reported here for the first time. This study identified 1-O-(4-coumaroyl)-β-d-glucopyranose (7) as the main compound responsible for the glucose uptake stimulation effect exerted by the extract.

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